Low levels of inertia due to increasing renewable penetration bring several challenges, such as the higher need for Primary Frequency Response (PFR). A potential solution to mitigate this problem consists on reducing the largest possible power loss in the grid. This paper develops a novel modelling framework to analyse the benefits of such approach.A new frequency-constrained Stochastic Unit Commitment (SUC) is proposed here, which allows to dynamically reduce the largest possible loss in the optimisation problem. Furthermore, the effect of load damping is included by means of an approximation, while its effect is typically neglected in previous frequency-secured-UC studies. Through several case studies, we demonstrate that reducing the largest loss could significantly decrease operational cost and carbon emissions in the future Great Britain's grid.