Invited review: Translating kisspeptin and neurokinin B biology into new therapies for reproductive health
Author(s)
Mills, Edouard G
Dhillo, Waljit S
Type
Journal Article
Abstract
The reproductive neuropeptide kisspeptin has emerged as the master regulator of mammalian reproduction due to its key roles in the initiation of puberty and the control of fertility. Alongside the tachykinin neurokinin B and the endogenous opioid dynorphin, these peptides are central to the hormonal control of reproduction. Building on the expanding body of experimental animal models, interest has flourished with human studies revealing that kisspeptin administration stimulates physiological reproductive hormone secretion in both healthy men and women, as well as patients with common reproductive disorders. In addition, emerging therapeutic roles based on neurokinin B for the management of menopausal flushing, endometriosis and uterine fibroids are increasingly recognised. In this review, we focus on kisspeptin and neurokinin B and their potential application as novel clinical strategies for the management of reproductive disorders.
Date Issued
2022-10
Date Acceptance
2022-09-06
Citation
Journal of Neuroendocrinology, 2022, 34 (10)
ISSN
0953-8194
Publisher
Wiley
Journal / Book Title
Journal of Neuroendocrinology
Volume
34
Issue
10
Copyright Statement
© 2022 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Identifier
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000870036700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
Subjects
ARCUATE NUCLEUS
Endocrinology & Metabolism
fertility
GONADOTROPIN-SECRETION
HORMONE-RELEASE
HYPOGONADOTROPIC HYPOGONADISM
HYPOTHALAMIC AMENORRHEA
KISS1 GENE-EXPRESSION
kisspeptin
LH-SECRETION
Life Sciences & Biomedicine
MONKEY MACACA-MULATTA
neurokinin B
Neurosciences
Neurosciences & Neurology
OVARIAN HYPERSTIMULATION SYNDROME
PROTEIN-COUPLED RECEPTOR
reproduction
Science & Technology
Publication Status
Published
Article Number
e13201
Date Publish Online
2022-09-17