Vascular and plaque imaging with ultrasmall superparamagnetic particles of iron oxide
Author(s)
Type
Journal Article
Abstract
Cardiovascular Magnetic Resonance (CMR) has become a primary tool for non-invasive assessment of cardiovascular anatomy, pathology and function. Existing contrast agents have been utilised for the identification of infarction, fibrosis, perfusion deficits and for angiography. Novel ultrasmall superparamagnetic particles of iron oxide (USPIO) contrast agents that are taken up by inflammatory cells can detect cellular inflammation non-invasively using CMR, potentially aiding the diagnosis of inflammatory medical conditions, guiding their treatment and giving insight into their pathophysiology. In this review we describe the utilization of USPIO as a novel contrast agent in vascular disease.
Date Issued
2015-09-18
Date Acceptance
2015-08-16
Citation
Journal of Cardiovascular Magnetic Resonance, 2015, 17, pp.1-9
ISSN
1097-6647
Publisher
BioMed Central
Start Page
1
End Page
9
Journal / Book Title
Journal of Cardiovascular Magnetic Resonance
Volume
17
Copyright Statement
© 2015 Alam et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000361356200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Radiology, Nuclear Medicine & Medical Imaging
Cardiovascular System & Cardiology
USPIO
Nanoparticles
CMR
Cardiovascular imaging
Inflammation
Macrophage
ENHANCED MAGNETIC-RESONANCE
ASYMPTOMATIC CAROTID ATHEROMA
CEREBRAL-ARTERY OCCLUSION
MR SIGNAL CHARACTERISTICS
IN-VIVO MRI
ATHEROSCLEROTIC PLAQUES
CONTRAST AGENT
MYOCARDIAL-INFARCTION
HYPERLIPIDEMIC RABBITS
INFLAMMATORY BURDEN
Publication Status
Published
Article Number
ARTN 83
Date Publish Online
2015-09-18