Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output
Author(s)
Udakis, Matt
Pedrosa, Victor
Chamberlain, Sophie EL
Clopath, Claudia
Mellor, Jack R
Type
Journal Article
Abstract
The formation and maintenance of spatial representations within hippocampal cell assemblies is strongly dictated by patterns of inhibition from diverse interneuron populations. Although it is known that inhibitory synaptic strength is malleable, induction of long-term plasticity at distinct inhibitory synapses and its regulation of hippocampal network activity is not well understood. Here, we show that inhibitory synapses from parvalbumin and somatostatin expressing interneurons undergo long-term depression and potentiation respectively (PV-iLTD and SST-iLTP) during physiological activity patterns. Both forms of plasticity rely on T-type calcium channel activation to confer synapse specificity but otherwise employ distinct mechanisms. Since parvalbumin and somatostatin interneurons preferentially target perisomatic and distal dendritic regions respectively of CA1 pyramidal cells, PV-iLTD and SST-iLTP coordinate a reprioritisation of excitatory inputs from entorhinal cortex and CA3. Furthermore, circuit-level modelling reveals that PV-iLTD and SST-iLTP cooperate to stabilise place cells while facilitating representation of multiple unique environments within the hippocampal network.
Date Issued
2020-09-02
Date Acceptance
2020-07-31
Citation
Nature Communications, 2020, 11 (1), pp.4395-4395
ISSN
2041-1723
Publisher
Nature Research
Start Page
4395
End Page
4395
Journal / Book Title
Nature Communications
Volume
11
Issue
1
Copyright Statement
© The Author(s) 2020. This article is licensed under a Creative CommonsAttribution 4.0 International License, which permits use, sharing,adaptation, distribution and reproduction in any medium or format, as long as you giveappropriate credit to the original author(s) and the source, provide a link to the CreativeCommons license, and indicate if changes were made. The images or other third partymaterial in this article are included in the article’s Creative Commons license, unlessindicated otherwise in a credit line to the material. If material is not included in thearticle’s Creative Commons license and your intended use is not permitted by statutoryregulation or exceeds the permitted use, you will need to obtain permission directly fromthe copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
License URL
Sponsor
Wellcome Trust
Biotechnology and Biological Sciences Research Council (BBSRC)
Biotechnology and Biological Sciences Research Cou
Simons Foundation
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/32879322
PII: 10.1038/s41467-020-18074-8
Grant Number
200790/Z/16/Z
BB/P018785/1
ORCA 64155 (BB/N013956/1)
Award ID:564408
Subjects
Action Potentials
Animals
CA1 Region, Hippocampal
Calcium Channels, T-Type
Channelrhodopsins
Hippocampus
Interneurons
Mice
Optogenetics
Parvalbumins
Patch-Clamp Techniques
Pyramidal Cells
Signal Transduction
Somatostatin
Synapses
Hippocampus
Pyramidal Cells
Interneurons
Synapses
Animals
Mice
Somatostatin
Parvalbumins
Calcium Channels, T-Type
Patch-Clamp Techniques
Signal Transduction
Action Potentials
CA1 Region, Hippocampal
Optogenetics
Channelrhodopsins
Publication Status
Published
Coverage Spatial
England
Article Number
ARTN 4395
Date Publish Online
2020-09-02