Facile biosensors for rapid detection of COVID-19
File(s)Accepted version_Review COVID-19 Biosensors.pdf (1.13 MB)
Accepted version
Author(s)
Xu, Lizhou
Li, Danyang
Ramadan, Sami
Li, Yanbin
Klein, Norbert
Type
Journal Article
Abstract
Currently the world is being challenged by a public health emergency caused by the coronavirus pandemic (COVID-19). Extensive efforts in testing for coronavirus infection, combined with isolating infected cases and quarantining those in contact, have proven successful in bringing the epidemic under control. Rapid and facile screening of this disease is in high demand. This review summarises recent advances in strategies reported by international researchers and engineers concerning how to tackle COVID-19 via rapid testing, mainly through nucleic acid- and antibody- testing. The roles of biosensors as powerful analytical tools are emphasized for the detection of viral RNAs, surface antigens, whole viral particles, antibodies and other potential biomarkers in human specimen. We critically review in depth newly developed biosensing methods especially for in-field and point-of-care detection of SARS-CoV-2. Additionally, this review describes possible future strategies for virus rapid detection. It helps researchers working on novel sensor technologies to tailor their technologies in a way to address the challenge for effective detection of COVID-19.
Date Issued
2020-12-15
Date Acceptance
2020-09-30
Citation
Biosensors and Bioelectronics, 2020, 170, pp.1-13
ISSN
0956-5663
Publisher
Elsevier
Start Page
1
End Page
13
Journal / Book Title
Biosensors and Bioelectronics
Volume
170
Copyright Statement
© 2020 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (EPSRC)
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000597183000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
EP/M020398/1
EP/P02985X/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biophysics
Biotechnology & Applied Microbiology
Chemistry, Analytical
Electrochemistry
Nanoscience & Nanotechnology
Chemistry
Science & Technology - Other Topics
SARS-CoV-2
COVID-19
Rapid detection
Point-of-care testing
Coronavirus
Biosensor
INFLUENZA-VIRUS H5N1
CORONAVIRUS
SARS-COV-2
APTASENSOR
WUHAN
PNEUMONIA
SPECIMENS
OUTBREAK
SPIKE
Publication Status
Published
Article Number
ARTN 112673
Date Publish Online
2020-10-01