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Monoderm bacteria: the new frontier for type IV pilus biology
File(s)
Author(s)
Pelicic, Vladimir
Type
Journal Article
Abstract
In the diverse world of bacterial pili, type IV pili (Tfp) are unique for two reasons: their multifunctionality and ubiquity. This latter feature offers an extraordinary possibility, that is, to perform comparative studies in evolutionarily distant species in order to improve our fragmentary understanding of Tfp biology. Regrettably, such potential has remained largely untapped, because, for 20 years, Tfp have only been characterised in diderm bacteria. However, recent studies of Tfp in monoderms have started closing the gap, revealing many interesting commonalities and a few significant differences, extending the frontiers of knowledge of Tfp biology. Here, I review the current state of the art of the Tfp field in monoderm bacteria and discuss resulting implications for our general understanding of the assembly and function of these widespread filamentous nanomachines.
Date Issued
2019-12
Date Acceptance
2019-09-23
Citation
Molecular Microbiology, 2019, 112 (6), pp.1674-1683
URI
URL
DOI
ISSN
0950-382X
Publisher
Wiley
Start Page
1674
End Page
1683
Journal / Book Title
Molecular Microbiology
Volume
112
Issue
6
Copyright Statement
© 2019 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd

This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor
Medical Research Council (MRC)
Medical Research Council (MRC)
Identifier
https://onlinelibrary.wiley.com/doi/full/10.1111/mmi.14397
Grant Number
MR/J006874/1B
MR/P022197/1
Subjects
06 Biological Sciences
11 Medical and Health Sciences
07 Agricultural and Veterinary Sciences
Microbiology
Publication Status
Published
Date Publish Online
2019-09-25