Non-alcoholic fatty liver disease: a sign of systemic disease
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease and leading cause of cirrhosis in the United States and developed countries. NAFLD is closely associated with obesity, insulin resistance and metabolic syndrome, significantly contributing to the exacerbation of the latter. Although NAFLD represents the hepatic component of metabolic syndrome, it can also be found in patients prior to their presentation with other manifestations of the syndrome. The pathogenesis of NAFLD is complex and closely intertwined with insulin resistance and obesity. Several mechanisms are undoubtedly involved in its pathogenesis and progression. In this review, we bring together the current understanding of the pathogenesis that makes NAFLD a systemic disease.
Date Issued
2017-04-27
Date Acceptance
2017-04-23
Citation
Metabolism: clinical and experimental, 2017, 72, pp.94-108
ISSN
0026-0495
Publisher
Elsevier
Start Page
94
End Page
108
Journal / Book Title
Metabolism: clinical and experimental
Volume
72
Copyright Statement
© 2017 Elsevier Inc. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000404316600011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
Fatty liver
NAFLD
NASH
Insulin resistance
Obesity
MUSCLE INSULIN-RESISTANCE
CHRONIC KIDNEY-DISEASE
HEPATIC STELLATE CELLS
OBESE ZUCKER RAT
ADIPOSE-TISSUE
METABOLIC SYNDROME
CARDIOVASCULAR-DISEASE
LIPOPROTEIN-LIPASE
GENE-EXPRESSION
NITRIC-OXIDE
Publication Status
Published