Cancer gene therapy expanded and reached
its pinnacle
in research in the
last decade. Both viral and non
-
viral vectors have entered clinical trials
,
and significant
successes have been
achieved. However,
a
systemic administration of a vector
,
illustrating
safe, efficient
,
and targeted gene delivery to solid tumors has
proven to be
a major challenge.
In this review, we summarize
the
current progress and challenges in
the
targeted gene
therapy
of cancer. Moreover, we highlight the recent developments of bacteriophage
-
derived
vectors and their contributions in targeting
cancer with
therapeutic genes following
systemic administration.