The pathobiology of IL-11 in kidney disease: from epithelial cell to fibroblast and back again
File(s)
Published version
Author(s)
Widjaja, Anissa A
Cook, Stuart A
Type
Journal Article
Abstract
Up to 25% of adults >60 years of age have chronic kidney disease (CKD), which represents a growing global health challenge. Some progress has been made in treating kidney diseases in recent years, but CKD for the most part remains progressive and leads to end-stage kidney disease, with the subsequent need for renal replacement therapy (life-long dialysis or renal transplantation). Although CKD can arise from a multitude of factors, including infections, obstructions, toxins, genetics, hemodynamics, and metabolic issues, renal fibrosis emerges as a common consequence of each of these triggers. Of all the CKD pathologies, extent of fibrosis most accurately predicts progression to end-stage kidney disease and poor clinical outcomes.
Date Issued
2023-12
Date Acceptance
2023-09-20
Citation
American Journal of Pathology, 2023, 193 (12), pp.1910-1912
ISSN
0002-9440
Publisher
Elsevier
Start Page
1910
End Page
1912
Journal / Book Title
American Journal of Pathology
Volume
193
Issue
12
Copyright Statement
Copyright © 2023 American Society for Investigative Pathology. Published by Elsevier Inc.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0).
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0).
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/37816442
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2023-10-09