Refeeding hypophosphatemia in adolescents with anorexia nervosa: a systematic review
Author(s)
O'Connor, Graeme
Nicholls, Dasha
Type
Journal Article
Abstract
The rate of adolescents presenting with anorexia nervosa (AN) is increasing. Medically unstable adolescents are admitted to the hospital for nutrition restoration. A lack of global consensus on appropriate refeeding practices of malnourished patients has resulted in inconsistent refeeding practices. Refeeding hypophosphatemia (RH) is the most common complication associated with refeeding the malnourished patient. This review sought to identify the range of refeeding rates adopted globally and the implication that total energy intake and malnutrition may have on RH while refeeding adolescents with anorexia nervosa. Studies were identified by a systematic electronic search of medical databases from 1980 to September 2012. Seventeen publications were identified, including 6 chart reviews, 1 observational study, and 10 case reports, with a total of 1039 subjects. The average refeeding energy intake was 1186 kcal/d, ranging from 125–1900 kcal/d, with a mean percentage median body mass index (% mBMI) of 78%. The average incidence rate of RH was 14%. A significant correlation between malnutrition (% mBMI) and post‐refeeding phosphate was identified (R 2 = 0.6, P = .01). This review highlights the disparity in refeeding rates adopted internationally in treating malnourished adolescents with anorexia nervosa. Based on this review, the severity of malnutrition seems to be a marker for the development of RH more so than total energy intake.
Date Issued
2013-06-01
Date Acceptance
2013-03-01
Citation
Nutrition in Clinical Practice, 2013, 28 (3), pp.358-364
ISSN
0884-5336
Publisher
Wiley
Start Page
358
End Page
364
Journal / Book Title
Nutrition in Clinical Practice
Volume
28
Issue
3
Copyright Statement
© 2013 by The American Society for Parenteral and Enteral Nutrition
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000318636900007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
hypophosphatemia
anorexia nervosa
adolescent
refeeding syndrome
RESTING ENERGY-EXPENDITURE
TOTAL PARENTERAL-NUTRITION
EATING-DISORDERS
HOSPITALIZED ADOLESCENTS
BODY-COMPOSITION
COMPLICATIONS
DELIRIUM
FAILURE
SAFETY
GIRLS
Publication Status
Published
Date Publish Online
2013-03-04