Unravelling the role of fatty acid metabolism in cancer through the FOXO3-FOXM1 axis.
Author(s)
Saavedra-García, P
Nichols, K
Mahmud, Z
Fan, LY
Lam, EW
Type
Journal Article
Abstract
Obesity and cachexia represent divergent states of nutritional and metabolic imbalance but both are intimately linked to cancer. There is an extensive overlap in their signalling pathways and molecular components involved such as fatty acids (FAs), which likely play a crucial role in cancer. Forkhead box (FOX) proteins are responsible of a wide range of transcriptional programmes during normal development, and the FOXO3-FOXM1 axis is associated with cancer initiation, progression and drug resistance. Free fatty acids (FFAs), FA synthesis and β-oxidation are associated with cancer development and progression. Meanwhile, insulin and some adipokines, that are up-regulated by FAs, are also involved in cancer development and poor prognosis. In this review, we discuss the role of FA metabolism in cancer and how FA metabolism integrates with the FOXO3-FOXM1 axis. These new insights may provide leads to better cancer diagnostics as well as strategies for tackling cancer development, progression and drug resistance.
Date Issued
2017-01-11
Date Acceptance
2017-01-09
Citation
Molecular and Cellular Endocrinology, 2017, (2017)
ISSN
1872-8057
Publisher
Elsevier
Journal / Book Title
Molecular and Cellular Endocrinology
Issue
2017
Replaces
Copyright Statement
©
2017 Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license (
http://
creativecommons.org/licenses/by/4.0/
).
2017 Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license (
http://
creativecommons.org/licenses/by/4.0/
).
Identifier
http://www.ncbi.nlm.nih.gov/pubmed/28087388
PII: S0303-7207(17)30016-3
Subjects
AKT/PI3K pathway
Cancer
FOXM1
FOXO3
Fatty acids
Lipid metabolism
Endocrinology & Metabolism
06 Biological Sciences
11 Medical And Health Sciences
07 Agricultural And Veterinary Sciences
Publication Status
Published
Coverage Spatial
Ireland