Assessing potential toxicity and metal bioavailability of secondary microplastics using in-vitro human gastric models
File(s)
Author(s)
Jones, Lorna Rhian
Type
Thesis
Abstract
Human Microplastic (MP) oral exposure is estimated at <168,000 environmental MP particles per day. Oral exposure risk from MP is not well understood, specifically within the gastrointestinal tract (GIT) environment. Observations of inflammation, down regulation of cell growth, metabolic disruption and reactive oxygen species post MP exposure have all occur in GIT models. However, these studies often have limitations such as the use of a primary polymer MP that does not accurately represent environmental exposure which occurs from finished product plastic 1 materials.
Version
Open Access
Date Issued
2024-06-16
Date Awarded
01/07/2025
License URL
Advisor
Wright, Stephanie
Gant, Timothy
Publisher Department
School of Public Health
Publisher Institution
Imperial College London
Qualification Level
Doctoral
Qualification Name
Doctor of Philosophy (PhD)