pRotective vEntilation with veno-venouS lung assisT in respiratory failure: A protocol for a multicentre randomised controlled trial of extracorporeal carbon dioxide removal in patients with acute hypoxaemic respiratory failure
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
One of the few interventions to demonstrate improved outcomes for acute hypoxaemic respiratory failure is reducing tidal volumes when using mechanical ventilation, often termed lung protective ventilation. Veno-venous extracorporeal carbon dioxide removal (vv-ECCO2R) can facilitate reducing tidal volumes. pRotective vEntilation with veno-venouS lung assisT (REST) is a randomised, allocation concealed, controlled, open, multicentre pragmatic trial to determine the clinical and cost-effectiveness of lower tidal volume mechanical ventilation facilitated by vv-ECCO2R in patients with acute hypoxaemic respiratory failure. Patients requiring intubation and mechanical ventilation for acute hypoxaemic respiratory failure will be randomly allocated to receive either vv-ECCO2R and lower tidal volume mechanical ventilation or standard care with stratification by recruitment centre. There is a need for a large randomised controlled trial to establish whether vv-ECCO2R in acute hypoxaemic respiratory failure can allow the use of a more protective lung ventilation strategy and is associated with improved patient outcomes.
Date Issued
2016-12-19
Date Acceptance
2016-10-16
Citation
Journal of the Intensive Care Society, 2016, 18 (2), pp.159-169
ISSN
1751-1437
Publisher
Sage Publications
Start Page
159
End Page
169
Journal / Book Title
Journal of the Intensive Care Society
Volume
18
Issue
2
Copyright Statement
© The Intensive Care Society 2016.
Sponsor
The Intensive Care Foundation
Intensive Care Society
Grant Number
Deputy Director of Research
Co-Director of Research
Publication Status
Published