The global meningitis genome partnership.
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Published version
Author(s)
Type
Journal Article
Abstract
Genomic surveillance of bacterial meningitis pathogens is essential for effective disease control globally, enabling identification of emerging and expanding strains and consequent public health interventions. While there has been a rise in the use of whole genome sequencing, this has been driven predominately by a subset of countries with adequate capacity and resources. Global capacity to participate in surveillance needs to be expanded, particularly in low and middle-income countries with high disease burdens. In light of this, the WHO-led collaboration, Defeating Meningitis by 2030 Global Roadmap, has called for the establishment of a Global Meningitis Genome Partnership that links resources for: N. meningitidis (Nm), S. pneumoniae (Sp), H. influenzae (Hi) and S. agalactiae (Sa) to improve worldwide co-ordination of strain identification and tracking. Existing platforms containing relevant genomes include: PubMLST: Nm (31,622), Sp (15,132), Hi (1935), Sa (9026); The Wellcome Sanger Institute: Nm (13,711), Sp (> 24,000), Sa (6200), Hi (1738); and BMGAP: Nm (8785), Hi (2030). A steering group is being established to coordinate the initiative and encourage high-quality data curation. Next steps include: developing guidelines on open-access sharing of genomic data; defining a core set of metadata; and facilitating development of user-friendly interfaces that represent publicly available data.
Date Issued
2020-06-29
Date Acceptance
2020-06-26
Citation
Journal of Infection, 2020, 4 (4), pp.510-520
ISSN
0163-4453
Publisher
British Infection Society
Start Page
510
End Page
520
Journal / Book Title
Journal of Infection
Volume
4
Issue
4
Copyright Statement
© 2020 The Authors. Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY-NC-ND license.
(http://creativecommons.org/licenses/by-nc-nd/4.0/)
(http://creativecommons.org/licenses/by-nc-nd/4.0/)
Sponsor
Wellcome Trust
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/32615197
PII: S0163-4453(20)30446-1
Grant Number
206394/Z/17/Z
Subjects
Bacterial meningitis
Epidemiology
Genome partnership
Haemophilus influenzae
Neisseria meningitidis
Streptococcus agalactiae
Streptococcus pneumoniae
Whole genome sequencing
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2020-06-29