Meta-analysis and meta-regression analysis of outcomes of endovascular and open repair for ruptured abdominal aortic aneurysm
File(s)RAAA Metanalysis Manuscript 25.12.docx (1.18 MB)
Accepted version
Author(s)
Type
Journal Article
Abstract
Objectives
The aim was to assess peri-operative mortality of endovascular aneurysm repair (EVAR) vs. open repair for ruptured abdominal aortic aneurysm (AAA) and to investigate whether outcomes have improved over the years and whether there is an association between institutional caseload and peri-operative mortality.
Methods
Electronic information sources (MEDLINE, EMBASE, CINAHL and CENTRAL) were searched up to August 2019. A systematic review was carried out according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines using a registered protocol (CRD42018106084). Studies were selected that reported peri-operative mortality of EVAR for ruptured AAA. A proportion meta-analysis was conducted, and summary estimates of odds ratios (ORs) and 95% confidence intervals (CIs) for EVAR vs. open surgical repair were obtained using random effects models. Mixed effects regression models were developed to investigate outcome changes over time and with institutional caseload.
Results
One hundred and thirty-six studies were included in quantitative synthesis reporting a total of 267 259 patients (EVAR 58 273; open surgery 208 986). The pooled peri-operative mortality of EVAR and open surgical repair was 0.245 (95% CI 0.234–0.257) and 0.378 (95% CI 0.364–0.392), respectively. EVAR was associated with reduced peri-operative mortality (OR 0.54, 95% CI 0.51–0.57, p < .001). Meta-regression analysis found decreasing peri-operative mortality over the years following EVAR (p < .001) and open repair (p < .001), and a decreasing OR of peri-operative mortality in favour of EVAR (p = .053). Meta-regression found a significant positive association between peri-operative mortality and institutional case load for open repair (p = .004).
Conclusions
If EVAR can be done, it is a better treatment for ruptured AAA in view of the reduced peri-operative mortality compared with open surgery. The outcomes of both EVAR and open surgical repair have improved over the years, and the difference in peri-operative mortality in favour of EVAR has become more pronounced. There is a significant association between peri-operative mortality and institutional case load for open repair of ruptured AAA.
The aim was to assess peri-operative mortality of endovascular aneurysm repair (EVAR) vs. open repair for ruptured abdominal aortic aneurysm (AAA) and to investigate whether outcomes have improved over the years and whether there is an association between institutional caseload and peri-operative mortality.
Methods
Electronic information sources (MEDLINE, EMBASE, CINAHL and CENTRAL) were searched up to August 2019. A systematic review was carried out according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines using a registered protocol (CRD42018106084). Studies were selected that reported peri-operative mortality of EVAR for ruptured AAA. A proportion meta-analysis was conducted, and summary estimates of odds ratios (ORs) and 95% confidence intervals (CIs) for EVAR vs. open surgical repair were obtained using random effects models. Mixed effects regression models were developed to investigate outcome changes over time and with institutional caseload.
Results
One hundred and thirty-six studies were included in quantitative synthesis reporting a total of 267 259 patients (EVAR 58 273; open surgery 208 986). The pooled peri-operative mortality of EVAR and open surgical repair was 0.245 (95% CI 0.234–0.257) and 0.378 (95% CI 0.364–0.392), respectively. EVAR was associated with reduced peri-operative mortality (OR 0.54, 95% CI 0.51–0.57, p < .001). Meta-regression analysis found decreasing peri-operative mortality over the years following EVAR (p < .001) and open repair (p < .001), and a decreasing OR of peri-operative mortality in favour of EVAR (p = .053). Meta-regression found a significant positive association between peri-operative mortality and institutional case load for open repair (p = .004).
Conclusions
If EVAR can be done, it is a better treatment for ruptured AAA in view of the reduced peri-operative mortality compared with open surgery. The outcomes of both EVAR and open surgical repair have improved over the years, and the difference in peri-operative mortality in favour of EVAR has become more pronounced. There is a significant association between peri-operative mortality and institutional case load for open repair of ruptured AAA.
Date Issued
2020-03
Date Acceptance
2019-12-09
Citation
European Journal of Vascular and Endovascular Surgery, 2020, 59 (3), pp.399-410
ISSN
1078-5884
Publisher
Elsevier BV
Start Page
399
End Page
410
Journal / Book Title
European Journal of Vascular and Endovascular Surgery
Volume
59
Issue
3
Copyright Statement
© 2020 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Department of Health
National Institute for Health Research Health Technology Assessment Programme
Identifier
https://www.sciencedirect.com/science/article/pii/S1078588419326929?via%3Dihub
Grant Number
07/37/64
HTA project 07/37/64
Subjects
Science & Technology
Life Sciences & Biomedicine
Surgery
Peripheral Vascular Disease
Cardiovascular System & Cardiology
Abdominal aortic aneurysm
Rupture
Endovascular aneurysm repair
EVAR
RANDOMIZED-TRIALS
MORTALITY
SURGEON
VOLUME
Abdominal aortic aneurysm
EVAR
Endovascular aneurysm repair
Rupture
Aortic Aneurysm, Abdominal
Aortic Rupture
Blood Vessel Prosthesis Implantation
Endovascular Procedures
Humans
Postoperative Complications
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
Humans
Aortic Rupture
Aortic Aneurysm, Abdominal
Postoperative Complications
Treatment Outcome
Blood Vessel Prosthesis Implantation
Risk Assessment
Risk Factors
Time Factors
Endovascular Procedures
1102 Cardiorespiratory Medicine and Haematology
1103 Clinical Sciences
Cardiovascular System & Hematology
Publication Status
Published online
Date Publish Online
2020-01-11