Reversal and remission of T2DM - an update for practitioners
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Accepted version
Author(s)
Type
Journal Article
Abstract
Over the past 50 years, many countries around the world have faced an unchecked pandemic of obesity and type 2 diabetes (T2DM). As best practice treatment of T2DM has done very little to check its growth, the pandemic of diabesity now threatens to make health-care systems economically more difficult for governments and individuals to manage within their budgets. The conventional view has been that T2DM is irreversible and progressive. However, in 2016, the World Health Organization (WHO) global report on diabetes added for the first time a section on diabetes reversal and acknowledged that it could be achieved through a number of therapeutic approaches. Many studies indicate that diabetes reversal, and possibly even long-term remission, is achievable, belying the conventional view. However, T2DM reversal is not yet a standardized area of practice and some questions remain about long-term outcomes. Diabetes reversal through diet is not articulated or discussed as a first-line target (or even goal) of treatment by any internationally recognized guidelines, which are mostly silent on the topic beyond encouraging lifestyle interventions in general. This review paper examines all the sustainable, practical, and scalable approaches to T2DM reversal, highlighting the evidence base, and serves as an interim update for practitioners looking to fill the practical knowledge gap on this topic in conventional diabetes guidelines.
Date Issued
2022-06-14
Date Acceptance
2022-05-10
Citation
Vascular Health and Risk Management, 2022, 18, pp.417-443
ISSN
1176-6344
Publisher
Dove Medical Press
Start Page
417
End Page
443
Journal / Book Title
Vascular Health and Risk Management
Volume
18
Copyright Statement
© 2022 Shibib et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.
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permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php)
php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the
work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For
permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php)
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000811882100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Peripheral Vascular Disease
Cardiovascular System & Cardiology
weight loss
very low energy
very low calorie
bariatric surgery
orlistat
electrical muscle stimulation
low carbohydrate
behaviour change
diabetes reversal
diabetes remission
LOW-CARBOHYDRATE-DIET
CARDIOVASCULAR RISK-FACTORS
TYPE-2 DIABETES-MELLITUS
LOW-FAT DIET
BETA-CELL FUNCTION
LOW-CALORIE DIET
NEUROMUSCULAR ELECTRICAL-STIMULATION
GLUCAGON-LIKE PEPTIDE-1
Y GASTRIC BYPASS
LAPAROSCOPIC SLEEVE GASTRECTOMY
Publication Status
Published