A shared mechanism of muscle wasting in cancer and Huntington's disease.
File(s)
Published version
Author(s)
Mielcarek, M
Isalan, M
Type
Journal Article
Abstract
Skeletal muscle loss and dysfunction in aging and chronic diseases is one of the major causes of mortality in patients, and is relevant for a wide variety of diseases such as neurodegeneration and cancer. Muscle loss is accompanied by changes in gene expression and metabolism that lead to contractile impairment and likely affect whole-body metabolism and function. The changes may be caused by inactivity, inflammation, age-related factors or unbalanced nutrition. Although links with skeletal muscle loss have been found in diseases with disparate aetiologies, for example both in Huntingtons disease (HD) and cancer cachexia, the outcome is a similar impairment and mortality. This short commentary aims to summarize recent achievements in the identification of common mechanisms leading to the skeletal muscle wasting syndrome seen in diseases as different as cancer and HD. The latter is the most common hereditary neurodegenerative disorder and muscle wasting is an important component of its pathology. In addition, possible therapeutic strategies for anti-cachectic treatment will be also discussed in the light of their translation into possible therapeutic approaches for HD.
Date Issued
2015-12-31
Start Page
34
Journal / Book Title
Clin Transl Med
Volume
4
Issue
1
Copyright Statement
© 2015 Mielcarek and Isalan. Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Identifier
http://www.ncbi.nlm.nih.gov/pubmed/26668061
10.1186/s40169-015-0076-z
Subjects
Cancer
Energy imbalance
Huntington’s disease
Muscle cachexia
Neurodegeneration
Skeletal muscle atrophy
Publication Status
Published
Coverage Spatial
Germany