Voltage amplification is an important element of the energy harvesting process to provide an enhanced voltage and run various digital circuits at low power. At RF frequencies, the discrete circuit arrangement using high frequency diode HSMS 2850 and capacitors have been used here to provide the voltage amplification with high power efficiency. The paper describes a mechanism of the Dickson circuit arrangement with its various parameters. The power efficiency is obtained and compared with multiple stages of the Dickson configuration for the input power, frequency of operation and its load using keysight based ADS tool. Finally a neural network has been designed using a Matlab script and the trained neural network has been applied to get the efficiency result. The result shows that with an increase in the multiplier stage of the Dickson circuit, there is a significant increase in its power efficiency. In addition the neural network implementation shows that the circuit parameters can be obtained using a well-trained neural network script.