Rats fed diets with different energy contribution from fat do not differ in adiposity
Author(s)
Type
Journal Article
Abstract
Objective: To determine whether rats reaching the same body mass, having been fed either a low-fat (LFD) or a high-fat diet (HFD), differ in white adipose tissue (WAT) deposition. Methods: In experiment 1, 22 Sprague-Dawley rats of the same age were divided into 11 rats with body mass below the batch median and fed a HFD, and 11 above the median and fed a LFD. In experiment 2, 20 Sprague-Dawley rats of the same age and starting body mass were randomised to either a HFD or LFD. When all groups reached similar final body mass, WAT was quantified using magnetic resonance imaging (MRI), dissection, and plasma leptin. Results: In experiment 1, both groups reached similar final body mass at the same age; in experiment 2 the HFD group reached similar final body mass earlier than the LFD group. There were no significant differences in WAT as assessed by MRI or leptin between the HFD and LFD groups in both experiments. Dissection revealed a trend for higher retroperitoneal and epididymal adiposity in the HFD groups in both experiments. Conclusions: We conclude that at similar body mass, adiposity is independent of the macronutrient composition of the feeding regimen used to achieve it.
Date Issued
2014-10-01
Date Acceptance
2014-08-01
Citation
Obesity Facts, 2014, 7 (5), pp.302-310
ISSN
1662-4025
Publisher
S. Karger AG
Start Page
302
End Page
310
Journal / Book Title
Obesity Facts
Volume
7
Issue
5
Copyright Statement
© 2014 S. Karger GmbH, Freiburg. This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC - https://creativecommons.org/licenses/by-nc/3.0/) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
Sponsor
Medical Research Council (MRC)
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344464000003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
G0902002
Subjects
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
Nutrition & Dietetics
High-fat diet
Low-fat diet
MRI
Leptin
INDUCED OBESITY
BODY-FAT
ISOCALORIC INTAKE
VISCERAL FAT
WEIGHT-GAIN
TISSUE
MASS
ACCUMULATION
EXPENDITURE
METABOLISM
Publication Status
Published
Date Publish Online
2014-10-01