A coordinated control strategy for insulin and glucagon delivery in type 1 diabetes
File(s)
Author(s)
Herrero, Pau
Bondia, Jorge
Oliver, Nick
Georgiou, Pantelis
Type
Journal Article
Abstract
Type 1 diabetes is an autoimmune condition characterised by a pancreatic insulin secretion deficit, resulting in high blood glucose concentrations, which can lead to micro- and macrovascular complications. Type 1 diabetes also leads to impaired glucagon production by the pancreatic α-cells, which acts as a counter-regulatory hormone to insulin. A closed-loop system for automatic insulin and glucagon delivery, also referred to as an artificial pancreas, has the potential to reduce the self-management burden of type 1 diabetes and reduce the risk of hypo- and hyperglycemia. To date, bihormonal closed-loop systems for glucagon and insulin delivery have been based on two independent controllers. However, in physiology, the secretion of insulin and glucagon in the body is closely interconnected by paracrine and endocrine associations. In this work, we present a novel biologically-inspired glucose control strategy that accounts for such coordination. An in silico study using an FDA-accepted type 1 simulator was performed to evaluate the proposed coordinated control strategy compared to its non-coordinated counterpart, as well as an insulin-only version of the controller. The proposed coordinated strategy achieves a reduction of hyperglycemia without increasing hypoglycemia, when compared to its non-coordinated counterpart.
Date Issued
2017-09-20
Date Acceptance
2017-09-07
Citation
Computer Methods in Biomechanics and Biomedical Engineering, 2017, 20 (13), pp.1474-1482
ISSN
1025-5842
Publisher
Taylor & Francis
Start Page
1474
End Page
1482
Journal / Book Title
Computer Methods in Biomechanics and Biomedical Engineering
Volume
20
Issue
13
Copyright Statement
© 2017 informa uK limited, trading as taylor & Francis group
Sponsor
Wellcome Trust
Wellcome Trust
Engineering & Physical Science Research Council (EPSRC)
Grant Number
089758/Z/09/Z
WT 100921/Z/13/Z
EP/P00993X/1
Subjects
Science & Technology
Technology
Computer Science, Interdisciplinary Applications
Engineering, Biomedical
Computer Science
Engineering
Artificial pancreas
diabetes
closed-loop control
bihormonal control
glucose control
insulin delivery
ARTIFICIAL PANCREAS
GLUCOSE
SECRETION
MODEL
Publication Status
Published