False lumen intervention to promote remodelling and thrombosisThe FLIRT concept in aortic dissection
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Accepted version
Author(s)
Type
Journal Article
Abstract
Objective
Thoracic endovascular aortic repair (TEVAR) has changed the management of aortic dissection by induced remodelling. Beyond reconstructing the true lumen, we describe the concept of False Lumen Intervention to promote Remodelling and Thrombosis (FLIRT) in both type A and B aortic dissection.
Methods
Between 2011 and 2017, 10 patients with aortic dissection (5 type A; 5 type B) underwent FLIRT using a combination of patent foramen ovale (PFO) or atrial septal defect (ASD) occluders, coils and glue. Patients were followed by computed tomography (CT) angiogram prior to, and 6 months following, discharge to evaluate false lumen (FL) thrombosis and aortic remodelling. Outcomes analyzed comprised successful device delivery, completeness of FL thrombosis and aortic remodelling, procedure related complications and mortality.
Results
FLIRT induced aortic remodelling in all cases of proximal dissection, with aortic shrinkage from 63.8 ± 7.5 pre‐FLIRT, to 50.2 ± 6.6 mm (P = 0.057) and an increase in true lumen area from 5.8 ± 3.6 to 11.4 ± 2.5 cm2 (P = 0.006). In distal dissection (after previous TEVAR with residual FL flow), FLIRT successfully induced FL thrombosis in 4 of 5 cases at first attempt (1 case required additional coiling of the gutter between left subclavian artery and stent‐graft for complete thrombosis). While maximal aortic diameter remained unchanged (55.6 ± 9.1 pre‐FLIRT and 54.4 ± 13.7 mm at follow‐up), true lumen area increased from 7.8 ± 2.3 pre‐procedure, to 10.6 ± 1.5 cm2 at follow‐up (P = 0.016), consistent with remodelling.
Conclusion
Interventional FL management, using the FLIRT concept, is feasible in selected cases of aortic dissection, promotes FL thrombosis and induces successful remodelling.
Thoracic endovascular aortic repair (TEVAR) has changed the management of aortic dissection by induced remodelling. Beyond reconstructing the true lumen, we describe the concept of False Lumen Intervention to promote Remodelling and Thrombosis (FLIRT) in both type A and B aortic dissection.
Methods
Between 2011 and 2017, 10 patients with aortic dissection (5 type A; 5 type B) underwent FLIRT using a combination of patent foramen ovale (PFO) or atrial septal defect (ASD) occluders, coils and glue. Patients were followed by computed tomography (CT) angiogram prior to, and 6 months following, discharge to evaluate false lumen (FL) thrombosis and aortic remodelling. Outcomes analyzed comprised successful device delivery, completeness of FL thrombosis and aortic remodelling, procedure related complications and mortality.
Results
FLIRT induced aortic remodelling in all cases of proximal dissection, with aortic shrinkage from 63.8 ± 7.5 pre‐FLIRT, to 50.2 ± 6.6 mm (P = 0.057) and an increase in true lumen area from 5.8 ± 3.6 to 11.4 ± 2.5 cm2 (P = 0.006). In distal dissection (after previous TEVAR with residual FL flow), FLIRT successfully induced FL thrombosis in 4 of 5 cases at first attempt (1 case required additional coiling of the gutter between left subclavian artery and stent‐graft for complete thrombosis). While maximal aortic diameter remained unchanged (55.6 ± 9.1 pre‐FLIRT and 54.4 ± 13.7 mm at follow‐up), true lumen area increased from 7.8 ± 2.3 pre‐procedure, to 10.6 ± 1.5 cm2 at follow‐up (P = 0.016), consistent with remodelling.
Conclusion
Interventional FL management, using the FLIRT concept, is feasible in selected cases of aortic dissection, promotes FL thrombosis and induces successful remodelling.
Date Issued
2018-10-01
Date Acceptance
2018-02-23
Citation
Catheterization and Cardiovascular Interventions, 2018, 92 (4), pp.732-740
ISSN
1522-1946
Publisher
Wiley
Start Page
732
End Page
740
Journal / Book Title
Catheterization and Cardiovascular Interventions
Volume
92
Issue
4
Copyright Statement
© 2019 Owner. This is the accepted version of the following article: Yuan, X, Mitsis, A, Semple, T, et al. False lumen intervention to promote remodelling and thrombosis—The FLIRT concept in aortic dissection. Catheter Cardiovasc Interv. 2018; 00: 1– 9. https://doi.org/10.1002/ccd.27599, which has been published in final form at https://doi.org/10.1002/ccd.27599.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000447803000020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
coils
false lumen
occluder devices
remodeling
thoracic endovascular aortic repair
vascular plug
ENDOVASCULAR ANEURYSM REPAIR
MIDTERM OUTCOMES
EMBOLIZATION
MANAGEMENT
ENDOLEAKS
Publication Status
Published
Date Publish Online
2018-03-30