Tumour necrosis factor-alpha (TNF-α)-induced metastatic phenotype in colorectal cancer epithelial cells: mechanistic support for the role of microRNA-21
File(s)
Published version
Author(s)
Li, Jia
Gooderham, Nigel
Alotaibi, Aminah
Type
Journal Article
Abstract
The progression of colorectal cancer is promoted by changes in the genetic makeup of tumour cells giving them potential to leave the site of their origin to seed new metastatic tumours in other tissue; inflammation at the tumour site is a driver of these changes. Tumour necrosis factor-alpha is a pro-inflammatory molecule that is associated with the progression of metastatic cancer. Small biologically active RNAs, microRNAs, target the production of specific proteins and are proposed as agents of tumour change. One agent, microRNA-21, shown to be present in colorectal cancer, is known to target the formation of proteins involved in metastatic changes in cells. We investigated the relationship between TNF-α and microRNA-21 in colorectal cancer cells and show their involvement in promoting cell changes indicative of the metastatic state. In summary, we provide mechanistic support for a role of microRNA-21 in tumour necrosis factor-alpha promotion of cancer cell metastatic change.
Date Issued
2023-01-19
Date Acceptance
2023-01-17
Citation
Cancers, 2023, 15 (3), pp.1-19
ISSN
2072-6694
Publisher
MDPI AG
Start Page
1
End Page
19
Journal / Book Title
Cancers
Volume
15
Issue
3
Copyright Statement
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
https://www.mdpi.com/2072-6694/15/3/627
Publication Status
Published
Article Number
627
Date Publish Online
2023-01-19