Epstein-Barr virus functional RNAs as part of its immune evasion strategy: a role for EBER1?
File(s)
Published version
Author(s)
Farrell, Paul J
Type
Journal Article
Abstract
Several types of cancer and some auto-immune diseases are linked to Epstein–Barr virus (EBV) infection. In addition to viral proteins, EBV expresses many functional RNAs to influence cell biology, avoiding the immune responses that would be targeted to viral proteins. Some of these RNAs are also exported from the EBV-infected cells into surrounding cells, including those involved in immune surveillance of the EBV infected cells. EBER1 is the most abundant of these EBV RNAs and recent progress in understanding EBER1 mechanisms might make it a drug target for some diseases associated with EBV.
Date Issued
2025-11-12
Date Acceptance
2025-10-02
Citation
Open Biology, 2025, 15 (11)
ISSN
2046-2441
Publisher
The Royal Society
Journal / Book Title
Open Biology
Volume
15
Issue
11
Copyright Statement
© 2025 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/41218767
Subjects
BINDING PROTEINS
Biochemistry & Molecular Biology
DOMAIN
EBER1
EBER2
Epstein-Barr virus
exosome
GENES
IDENTIFICATION
INFECTION
LATENCY
Life Sciences & Biomedicine
MICRORNAS
miRNA
RPL22
Science & Technology
T-CELL DEVELOPMENT
Publication Status
Published
Coverage Spatial
England
Article Number
250088
Date Publish Online
2025-11-12