Human haematopoietic stem cell (CD34+ subset) transplantation in acute ischaemic stroke
Author(s)
Banerjee, Soma
Type
Thesis
Abstract
Stroke is a leading cause of death and disability. Globally, 15 million people suffer a stroke each year, of whom more than 5 million die, and a further 5 million are left permanently disabled. Current treatment options offer modest benefits, and there is a pressing need for new and effective treatments.
Stem cell therapy is a well-established treatment modality for haematological diseases, with its use now being explored in different disease processes, including neurological diseases, as well as vascular conditions such as ischaemic heart disease and peripheral vascular disease. Promising results have been seen in animal models of stroke, with evidence of significant functional benefits. Translation to the bedside, however, is in its infancy.
Bone marrow is an attractive source of stem cells, being easily accessible, and suitable for autologous use. CD34+ cells represent a subset of bone marrow derived mononuclear cells which have been studied in pre-clinical models of stroke. This study investigates the potential therapeutic role of autologous CD34+ cells in acute ischaemic stroke patients in a Phase I clinical trial.
Stem cell therapy is a well-established treatment modality for haematological diseases, with its use now being explored in different disease processes, including neurological diseases, as well as vascular conditions such as ischaemic heart disease and peripheral vascular disease. Promising results have been seen in animal models of stroke, with evidence of significant functional benefits. Translation to the bedside, however, is in its infancy.
Bone marrow is an attractive source of stem cells, being easily accessible, and suitable for autologous use. CD34+ cells represent a subset of bone marrow derived mononuclear cells which have been studied in pre-clinical models of stroke. This study investigates the potential therapeutic role of autologous CD34+ cells in acute ischaemic stroke patients in a Phase I clinical trial.
Date Issued
2012-11
Date Awarded
2013-07
Copyright Statement
Attribution NoDerivatives 4.0 International Licence (CC BY-ND)
Advisor
Chataway, Jeremy
Habib, Nagy
Publisher Department
Medicine
Publisher Institution
Imperial College London
Qualification Level
Doctoral
Qualification Name
Doctor of Philosophy (PhD)