How does the hydrophobic content of methacrylate ABA triblock copolymers affect polymersome formation?
File(s)pol.20210371.pdf (1.45 MB)
Published version
OA Location
Author(s)
Zhang, Xinmo
Contini, Claudia
Constantinou, Anna
Doutch, James
Georgiou, Theonitsa
Type
Journal Article
Abstract
Polymersomes are exciting self-assembled structures with great potential in pharmaceutical applications. A systematic investigation of a novel series of methacrylate-based polymersomes is reported in this study. Five well-defined ABA triblock copolymers with A being based on tri(ethylene glycol) methyl methacrylate and B being based on 2-(diethylamino)ethyl methacrylate (DMAEMA) were synthesized using a living polymerization method. The effect of the composition of the ABA triblock copolymers on the thickness of the hydrophobic membrane of the polymersomes and the release of a model drug is demonstrated.
Date Issued
2021-08-01
Date Acceptance
2021-05-28
Citation
Journal of Polymer Science, 2021, 59 (15), pp.1724-1731
ISSN
2642-4169
Publisher
Wiley
Start Page
1724
End Page
1731
Journal / Book Title
Journal of Polymer Science
Volume
59
Issue
15
Copyright Statement
© 2021 The Authors. Journal of Polymer Science published by Wiley Periodicals LLC.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Identifier
https://onlinelibrary.wiley.com/doi/10.1002/pol.20210371
Subjects
Science & Technology
Physical Sciences
Polymer Science
2-(diethylamino)ethyl methacrylate
ABA triblock copolymers
poly(ethylene glycol) methyl methacrylate
polymersomes
self-assembly
GROUP-TRANSFER POLYMERIZATION
THERMORESPONSIVE GELS
RESPONSIVE POLYMERSOMES
GLYCOL) METHACRYLATE
AMPHIPHILIC DIBLOCK
VESICLES
PH
ARCHITECTURE
MICELLES
NANOREACTORS
Publication Status
Published
Date Publish Online
2021-06-14