This work reviews the best practices to reduce CO2 emissions in energy intensive organizations and energy value-chains by highlighting the synergy that can be built with like-minded organizations via collaborations; taking the Basque Country as a case study. An academic review covers how corporate strategies are attempting to curtail emissions in a systematic manner. The study is then complimented by findings obtained from interviews of key stakeholders in the Basque Country responsible for playing an important role in implementing a green agenda. The interviews allow us to highlight flagship projects and assess the collaborative framework strengths and challenges. Results indicate that organizations are well underway in implementing and researching low carbon solutions, but issues surrounding governance, strategy, and regulatory challenges can slow progress of goals.