The interplay between senescence, inflammation, and the immune system
File(s)
Published online version
Author(s)
Gil, Jesus
Type
Journal Article
Abstract
The past 40 years have witnessed significant progress in aging research. Although aging was once considered a stochastic process, it is now understood to be regulated by pathways and processes that can be dissected with modern cellular and molecular biology approaches. The aberrant accumulation of cells undergoing cellular senescence and an increase in chronic, sterile inflammation are two of those aging hallmarks. Here we discuss how these processes are connected and how the relationship between senescent cells and the immune system dictates the extent of inflammatory processes contributing to age-related dysfunction and disease.
Date Issued
2025-07-11
Date Acceptance
2025-06-23
Citation
Genes and Development, 2025
ISSN
0890-9369
Publisher
Cold Spring Harbor Laboratory Press
Journal / Book Title
Genes and Development
Copyright Statement
© 2025 Gil. This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/
License URL
Identifier
10.1101/gad.353125.125
Subjects
aging
senescence
inflammation]
Publication Status
Published online
Date Publish Online
2025-07-11