Mitochondrial deformation during the cardiac mechanical cycle
File(s)
Author(s)
Rog-Zielinska, EA
O'Toole, ET
Hoenger, A
Kohl, P
Type
Journal Article
Abstract
Cardiomyocytes both cause and experience continual cyclic deformation. The exact effects of this deformation on the properties of intracellular organelles are not well characterized, although they are likely to be relevant for cardiomyocyte responses to active and passive changes in their mechanical environment. In the present study we provide three‐dimensional ultrastructural evidence for mechanically induced mitochondrial deformation in rabbit ventricular cardiomyocytes over a range of sarcomere lengths representing myocardial tissue stretch, an unloaded “slack” state, and contracture. We also show structural indications for interaction of mitochondria with one another, as well as with other intracellular elements such as microtubules, sarcoplasmic reticulum and T‐tubules. The data presented here help to contextualize recent reports on the mechanosensitivity and cell‐wide connectivity of the mitochondrial network and provide a structural framework that may aide interpretation of mechanically‐regulated molecular signaling in cardiac cells. Anat Rec, 302:146–152, 2019. © 2018 The Authors. The Anatomical Record published by Wiley Periodicals, Inc. on behalf of American Association of Anatomists.
Date Issued
2019-01-01
Date Acceptance
2018-05-11
Citation
Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology, 2019, 302 (1), pp.146-152
ISSN
0749-3002
Publisher
Wiley
Start Page
146
End Page
152
Journal / Book Title
Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Volume
302
Issue
1
Copyright Statement
© 2018 The Authors. The Anatomical Record published by Wiley Periodicals, Inc. on behalf of American Association of Anatomists.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
License URL
Sponsor
British Heart Foundation
British Heart Foundation
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000459881400016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
FS/12/17/29532
FS/15/3/31047
Subjects
Science & Technology
Life Sciences & Biomedicine
Anatomy & Morphology
mitochondria
heart
mechanosensitivity
electron tomography
sarcoplasmic reticulum
SARCOPLASMIC-RETICULUM
ENDOPLASMIC-RETICULUM
VENTRICULAR MYOCYTES
RYANODINE RECEPTORS
CALCIUM-RELEASE
CA2+
TOMOGRAPHY
ALIGNMENT
STRETCH
MECHANOSENSITIVITY
Publication Status
Published
Date Publish Online
2018-10-10