Matrisome remodeling in the myocardium of hypertrophic cardiomyopathy; novel targets for molecular diagnostics
File(s)
Published version
Author(s)
Ibrahim, Ayman M
Elfawy, Hasnaa A
Terracciano, Cesare M
Yacoub, Magdi
Type
Journal Article
Abstract
Hypertrophic cardiomyopathy (HCM) is an inherited cardiac disorder characterized by left ventricular thickening and extracellular matrix (ECM) remodeling, often manifested as increased interstitial fibrosis that impair muscle function. The clinical and pathological presentations, as well as the genetic background, vary among patients, making HCM a heterogeneous disease with diverse clinical phenotyping and responses to treatment. In HCM, the myocardium exhibits an increased secretion of inflammatory mediators and ECM proteins, indicating a stress response to myocardial pathogenesis. The production of these ECM proteins is regulated by the interaction between cardiomyocytes and the surrounding stroma, including cardiac fibroblasts, immune cells, and microvasculature. This crosstalk defines the responsiveness to injury and the progression of the disease. In this review, we aim to dissect the composition of myocardial ECM in relation to HCM development, highlighting the key cellular contributions to ECM remodeling and identifying potential molecular targets for personalized diagnostics and therapeutics.
Date Issued
2025-08-06
Date Acceptance
2025-07-07
Citation
Frontiers in Cell and Developmental Biology, 2025, 13
ISSN
2296-634X
Publisher
Frontiers Media S.A.
Journal / Book Title
Frontiers in Cell and Developmental Biology
Volume
13
Copyright Statement
© 2025 Ibrahim, Elfawy, Terracciano and Yacoub. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/40843168
PII: 1641584
Subjects
ECM
HCM
inflammation
matrisome
secretome
Publication Status
Published
Coverage Spatial
Switzerland
Article Number
1641584
Date Publish Online
2025-08-06