A cognitive chameleon: lessons from a novel MAPT mutation case.
File(s)
Author(s)
Type
Journal Article
Abstract
We report a case of frontotemporal dementia caused by a novel MAPT mutation (Q351R) with a remarkably long amnestic presentation mimicking familial Alzheimer’s disease. Longitudinal clinical, neuropsychological and imaging data provide convergent evidence for predominantly bilateral anterior medial temporal lobe involvement consistent with previously established neuroanatomical signatures of MAPT mutations. This case supports the notion that the neural network affected in MAPT mutations is determined to a large extent by the underlying molecular pathology. We discuss the diagnostic significance of anomia in the context of atypical amnesia and the impact of impaired episodic and semantic memory systems on autobiographical memory.
Date Issued
2014
Date Acceptance
2013-08-06
Citation
Neurocase: The Neural Basis of Cognition, 2014, 20, pp.684-694
ISSN
1355-4794
Publisher
Routledge
Start Page
684
End Page
694
Journal / Book Title
Neurocase: The Neural Basis of Cognition
Volume
20
Copyright Statement
© 2013 The Author(s). Published by Taylor & Francis.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
License URL
Identifier
https://www.tandfonline.com/doi/full/10.1080/13554794.2013.826697
Subjects
Autobiographical memory
Brain networks
Episodic memory
Familial Alzheimer’s disease
Frontotemporal dementia
MAPT mutations
Semantic memory
Alzheimer Disease
Amnesia
Anomia
Brain
Disease Progression
Female
Frontotemporal Dementia
Hippocampus
Humans
Middle Aged
Mutation
tau Proteins
Brain
Hippocampus
Humans
Alzheimer Disease
Anomia
Amnesia
Disease Progression
tau Proteins
Mutation
Middle Aged
Female
Frontotemporal Dementia
1103 Clinical Sciences
1701 Psychology
1702 Cognitive Sciences
Experimental Psychology
Notes
urldate: 2020-08-20 pmid: 23998300 pmcid: PMC4151790 sciwheel-projects: My Publications
Publication Status
Published
Article Number
6
Date Publish Online
2013-09-02