Modification of the classical Lancefield assay of group A streptococcal killing to reduce inter donor variation
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Accepted version
Published version
Author(s)
Reglinski, M
Lynskey, NN
Sriskandan, S
Type
Journal Article
Abstract
The lack of a surrogate-of-immunity assay presents a major barrier to Streptococcus pyogenes
research. Modification of the Lancefield assay to include an antibody digestion step reduced interdonor
variation and permitted detection of the anti-streptococcal activity of intravenous
immunoglobulin and convalescent serum, thus facilitating retrospective evaluation of immunity
using stored samples.
research. Modification of the Lancefield assay to include an antibody digestion step reduced interdonor
variation and permitted detection of the anti-streptococcal activity of intravenous
immunoglobulin and convalescent serum, thus facilitating retrospective evaluation of immunity
using stored samples.
Date Issued
2016-03-24
Date Acceptance
2016-03-22
Citation
Journal of Microbiological Methods, 2016, 124, pp.69-71
ISSN
1872-8359
Publisher
Elsevier
Start Page
69
End Page
71
Journal / Book Title
Journal of Microbiological Methods
Volume
124
Copyright Statement
© 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/)
(http://creativecommons.org/licenses/by/4.0/)
License URL
Sponsor
Wellcome Trust
Medical Research Council (MRC)
National Institute for Health Research
Grant Number
087732/Z/08/Z
G0800777
RDA02 79560
Subjects
Group A streptococcus
Lancefield assay
Streptococcus pyogenes
Surrogate of immunity
Microbiology
0605 Microbiology
1108 Medical Microbiology
Publication Status
Published