Cable theory of protein receptor trafficking in a dendritic tree
File(s)
Published version
Author(s)
Bressloff, Paul C
Type
Journal Article
Abstract
We develop an application of linear cable theory to protein receptor trafficking in the surface membrane of a neuron’s dendritic tree. We assume that receptors diffuse freely in the dendritic membrane but exhibit periods of confined motion through interactions with small mushroomlike protrusions known as dendritic spines. We use cable theory to determine how receptor trafficking depends on the geometry of the dendritic tree and various important biophysical parameters such as membrane diffusivity, the density of spines, the strength of diffusive coupling between dendrites and spines, and the rates of constitutive recycling of receptors between the surface of spines and intracellular pools. We also use homogenization theory to determine corrections to cable theory arising from the discrete nature of spines.
Date Issued
2009-04
Date Acceptance
2009-04-01
Citation
Physical Review E: Statistical, Nonlinear, and Soft Matter Physics, 2009, 79 (4)
ISSN
1539-3755
Publisher
American Physical Society
Journal / Book Title
Physical Review E: Statistical, Nonlinear, and Soft Matter Physics
Volume
79
Issue
4
Copyright Statement
©2009 American Physical Society
Identifier
http://dx.doi.org/10.1103/physreve.79.041904
Publication Status
Published
Article Number
041904
Date Publish Online
2009-04-03