Kinase inhibitors and ovarian cancer
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Ovarian cancer is fifth in the rankings of cancer deaths among women, and accounts for more deaths than any other gynecological malignancy. Despite some improvement in overall-(OS) and progression-free survival (PFS) following surgery and first-line chemotherapy, there is a need for development of novel and more effective therapeutic strategies. In this mini review, we provide a summary of the current landscape of the clinical use of tyrosine kinase inhibitors (TKIs) and mechanistic target of rapamycin (mTOR) inhibitors in ovarian cancer. Emerging data from phase I and II trials reveals that a combinatorial treatment that includes TKIs and chemotherapy agents seems promising in terms of PFS despite some adverse effects recorded; whereas the use of mTOR inhibitors seems less effective. There is a need for further research into the inhibition of multiple signaling pathways in ovarian cancer and progression to phase III trials for drugs that seem most promising.
Date Issued
2019-09-01
Date Acceptance
2019-09-09
Citation
Cancers, 2019, 11 (9)
ISSN
2072-6694
Publisher
MDPI AG
Journal / Book Title
Cancers
Volume
11
Issue
9
Copyright Statement
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000489719000142&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
Subjects
BREAST-CANCER
DAYS ON/7 DAYS
IN-VIVO
kinase inhibitors
Life Sciences & Biomedicine
mTOR
Oncology
ovarian cancer
PHASE-II TRIAL
PLACEBO-CONTROLLED TRIAL
PLATINUM-REFRACTORY/RESISTANT OVARIAN
PRIMARY PERITONEAL CARCINOMA
rapalogs
RECURRENT EPITHELIAL OVARIAN
Science & Technology
SOLID TUMORS
TARGETED THERAPY
TKI
Publication Status
Published
Coverage Spatial
Switzerland
Article Number
1357
Date Publish Online
2019-09-12