Real-time imaging of retinal cell apoptosis by confocal scanning laser ophthalmoscopy and its role in glaucoma
File(s)
Published version
Author(s)
Yang, Elizabeth
Al-Mugheiry, Toby S
Normando, Eduardo M
Cordeiro, Maria F
Type
Journal Article
Abstract
Glaucoma is one of the leading causes of irreversible blindness in the world. It is characterized by the progressive loss of retinal ganglion cells (RGCs), mainly through the process of apoptosis. Glaucoma patients often come to clinical attention when irreversible loss of visual function has been already established; therefore, early recognition of RGC apoptosis is inordinately important in disease prevention. The novel technology called Detection of Apoptosing Retinal Cells (DARC) allows real-time in vivo quantification of apoptosing cells through the use of a fluorescent biomarker and a confocal scanning ophthalmoscope. A recent Phase I clinical trial has evaluated the safety of DARC and its ability to detect retinal apoptosis in glaucoma patients and healthy volunteers. Results suggest that DARC may have potential in the early detection of glaucoma, which could help alleviate the medical, social, and economic burden associated with this blinding condition.
Date Issued
2018-05-15
Date Acceptance
2018-04-27
Citation
Frontiers in Neurology, 2018, 9
ISSN
1664-2295
Publisher
Frontiers Media
Journal / Book Title
Frontiers in Neurology
Volume
9
Copyright Statement
© 2018 Yang, Al-Mugheiry, Normando and Cordeiro. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY - https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000432399900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Neurosciences & Neurology
glaucoma
annexin
retinal ganglion cells
imaging
apoptosis
NORMAL-TENSION GLAUCOMA
INTRAOCULAR-PRESSURE
IN-VIVO
GANGLION-CELLS
DEATH
NEURODEGENERATION
ANNEXIN
EYE
MODULATION
NUMBER
Publication Status
Published
Article Number
338