Influence of right coronary artery motion, flow pulsatility and non-Newtonian rheology on wall shear stress metrics
File(s)
Published version
Author(s)
Weinberg, Peter
Kandangwa, Pratik
Torii, Ryo
Gatehouse, Peter
Sherwin, Spencer
Type
Journal Article
Abstract
The patchy distribution of atherosclerosis within the arterial system is consistent with a controlling influence of hemodynamic wall shear stress (WSS). Patterns of low, oscillatory and transverse WSS have been invoked to explain the distribution of disease in the aorta. Disease of coronary arteries has greater clinical importance but blood flow in these vessels may be complicated by their movement during the cardiac cycle. Previous studies have shown that time average WSS is little affected by the dynamic geometry, and that oscillatory shear is influenced more. Here we additionally investigate effects on transverse WSS. We also investigate the influence of non-Newtonian blood rheologyas it can influence vortical structure, on which transverse WSS depends; Carreau-Yasuda models were used. WSS metrics were derived from numerical simulations of blood flow in a model of a moving right coronary artery which, together with a subject-specific inflow waveform, was obtained by MR imaging of a healthy human subject in a previous study. The results confirmed that time average WSS was little affected by dynamic motion, and that oscillatory WSS was more affected. They additionally showed that transverse WSS and its non-dimensional analogue, the Cross Flow Index, were affected still further. This appeared to reflect time-varying vortical structures caused by the changes in curvature. The influence of non-Newtonian rheology was significant with some physiologically realistic parameter values, and hence may be important in certain subjects. Dynamic geometry and non-Newtonian rheology should be incorporated into models designed to produce maps of transverse WSS in coronary arteries.
Date Issued
2022-08-09
Date Acceptance
2022-07-06
Citation
Fontiers in Bioengineering and Biotechnology, 2022, 10, pp.1-14
ISSN
2296-4185
Publisher
Frontiers
Start Page
1
End Page
14
Journal / Book Title
Fontiers in Bioengineering and Biotechnology
Volume
10
Copyright Statement
Copyright © 2022 Kandangwa, Torii, Gatehouse, Sherwin and Weinberg. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
License URL
Sponsor
British Heart Foundation
Engineering and Physical Sciences Research Council
Grant Number
RG/11/5/28743
EP/L016230/1
Subjects
0699 Other Biological Sciences
0903 Biomedical Engineering
1004 Medical Biotechnology
Publication Status
Published
Article Number
962687
Date Publish Online
2022-08-09