Subcutaneous Phaeohyphomycosis Cyst Associated with Medicopsis romeroi in an Immunocompromised Host
File(s)
Author(s)
Type
Journal Article
Abstract
An 88-year-old man, receiving prednisolone for sarcoidosis, presented with a discrete keratotic lesion on the dorsum of his right hand following the placement of an intravenous cannula a month prior to its appearance. Medicopsis romeroi was isolated from the tissue and identified by sequencing the internal transcribed spacer region ITS-1 and the D1-2 fragment of the 28S rDNA gene. Histopathological examination showed fungal hyphae in the internal inflammatory cells layer and within the histocyte-macrophage layer, highly suggestive of deep mycosis. The patient was successfully treated with surgical excision of the cyst. M. romeroi exhibited high MIC values for echinocandin drugs in vitro, but appeared susceptible to newer triazole agents, amphotericin B and terbinafine. This is the first report of a subcutaneous phaeohyphomycotic cyst occurring following the placement of an intravenous cannula. This report highlights the potential role of M. romeroi as an emerging cause of deep, non-mycetomatous infection in immunocompromised patients.
Date Issued
2016-05-18
Date Acceptance
2016-05-05
Citation
Mycopathologia, 2016, 181 (9), pp.717-721
ISSN
1573-0832
Publisher
Springer Verlag (Germany)
Start Page
717
End Page
721
Journal / Book Title
Mycopathologia
Volume
181
Issue
9
Copyright Statement
© The Author(s) 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
License URL
Identifier
PII: 10.1007/s11046-016-0017-4
Subjects
Antifungal susceptibility testing
Medicopsis romeroi
Mycoses
Phaeohyphomycoses
Subcutaneous cyst
Microbiology
0607 Plant Biology
Publication Status
Published