Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase
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Accepted version
Published version
Author(s)
Type
Journal Article
Abstract
In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed “RU-SKI”) class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final compounds. RU-SKI compounds were selected for synthesis based on their published high potencies against the enzyme target. RU-SKI 41 (9a), RU-SKI 43 (9b), RU-SKI 101 (9c), and RU-SKI 201 (9d) were profiled for activity in the related article “Click chemistry armed enzyme linked immunosorbent assay to measure palmitoylation by Hedgehog acyltransferase” (Lanyon-Hogg et al., 2015) [1]. 1H NMR spectral data indicate different amide conformational ratios between the RU-SKI inhibitors, as has been observed in other 5-acyl-6,7-dihydrothieno[3,2-c]pyridines. The synthetic and characterisation data supplied in the current article provide validated access to the class of RU-SKI inhibitors.
Date Issued
2016-02-10
Date Acceptance
2016-02-01
Citation
Data in Brief, 2016, 7, pp.257-281
ISSN
2352-3409
Publisher
Elsevier
Start Page
257
End Page
281
Journal / Book Title
Data in Brief
Volume
7
Copyright Statement
© 2016 Published by Elsevier Inc. This is an open access article
under the CC BY license
(http://creativecommons.org/licenses/by/4.0/)
under the CC BY license
(http://creativecommons.org/licenses/by/4.0/)
License URL
Sponsor
Cancer Research UK
Grant Number
C6433/A16402
Subjects
Synthesis
Inhibitors
Hedgehog acyltransferase
Conformation
Publication Status
Published