Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρˆ| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
Date Issued
2016-04-18
Date Acceptance
2016-03-24
Citation
Nature Genetics, 2016, 48 (6), pp.624-633
ISSN
1061-4036
Publisher
Nature Publishing Group
Start Page
624
End Page
633
Journal / Book Title
Nature Genetics
Volume
48
Issue
6
Copyright Statement
© 2016 Nature America, Inc. All rights reserved
Subjects
Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
MAJOR DEPRESSION
COMMON VARIANTS
HUMAN HEIGHT
RISK
HERITABILITY
METAANALYSIS
PERSONALITY
HAPPINESS
RESOURCE
DISEASE
LifeLines Cohort Study
Developmental Biology
11 Medical And Health Sciences
06 Biological Sciences
Publication Status
Published