Exploring the pharmacokinetics of phenoxymethylpenicillin (Penicillin-V) in adults: a healthy volunteer study
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Published version
Author(s)
Type
Journal Article
Abstract
This healthy volunteer study aimed to explore Phenoxymethylpenicillin (Penicillin-V) pharmacokinetics (PK) to support the planning of large, dosing studies in adults. Volunteers were dosed with penicillin-V at steady state. Total and unbound penicillin-V serum concentration was determined and a base population PK model were fitted to the data.
Date Issued
2021-12
Date Acceptance
2021-11-11
Citation
Open Forum Infectious Diseases, 2021, 8 (12), pp.1-4
ISSN
2328-8957
Publisher
Oxford University Press
Start Page
1
End Page
4
Journal / Book Title
Open Forum Infectious Diseases
Volume
8
Issue
12
Copyright Statement
© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Sponsor
National Institute for Health Research
National Institute for Health Research
National Institute for Health Research
National Institute for Health Research
Identifier
https://academic.oup.com/ofid/article/8/12/ofab573/6469612
Grant Number
NF-SI-0617-10176
RDF04
NIHR200646
NIHR200876
Subjects
healthy volunteers
oral dosing
penicillin-V
pharmacokinetics
population PK modeling
Publication Status
Published
Date Publish Online
2021-12-18