Rear-end collisions are one of the most common types of accidents on roads. Global Satellite Navigation Systems (GNSS) have recently become sufficiently flexible and cost-effective in order to have great potential for use in rear-end collision avoidance systems (CAS). Nevertheless, there are two main issues associated with current vehicle rear-end CAS: (1) achieving relative vehicle positioning and dynamic parameters with sufficiently high accuracy and (2) a reliable method to extract the car-following status from such information. This paper introduces a novel integrated algorithm for rear-end collision detection. Access to high accuracy positioning is enabled by GNSS, electronic compass, and lane information fusion with Cubature Kalman Filter (CKF). The judgment of the car-following status is based on the application of the Adaptive Neurofuzzy Inference System (ANFIS). The field test results show that the designed algorithm could effectively detect rear-end collisions with an accuracy of 99.61% and a false alarm rate of 5.26% in the 10 Hz output rate.