The effect of lower limb revascularization on flow, perfusion, and systemic endothelial function: a systematic review.
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Peripheral arterial disease (PAD) is associated with reduced lower limb blood flow and tissue perfusion. The consequent reduction in vessel wall shear stress as well as ischemia-reperfusion injury has also been associated with systemic endothelial dysfunction and inflammation. We aimed to explore the impact of lower limb revascularization on (1) lower limb blood flow, (2) tissue perfusion, and (3) systemic endothelial function. We performed a systematic literature search using the MEDLINE, Embase, and Web of Science databases. Eligible studies measured changes in lower limb blood flow, perfusion, or systemic endothelial function following revascularization for the treatment of symptomatic PAD. We found 19 eligible studies, which were limited by considerable heterogeneity. Current evidence suggests that revascularization has a positive effect on flow, perfusion, and systemic endothelial dysfunction. Any changes may take a number of weeks to become apparent. There is a need for well-designed studies to explore the association between flow, perfusion, and endothelial dysfunction.
Date Issued
2021-03-01
Date Acceptance
2020-11-01
Citation
Angiology, 2021, 72 (3), pp.210-220
ISSN
0003-3197
Publisher
SAGE Publications
Start Page
210
End Page
220
Journal / Book Title
Angiology
Volume
72
Issue
3
Copyright Statement
© The Author(s) 2020. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
License URL
Sponsor
National Institute of Health Research
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/33143447
Subjects
flow
perfusion
peripheral arterial disease
revascularization
systemic endothelial function
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2020-11-04