IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and asthma status
File(s)2400005.full.pdf (394.15 KB)
Published version
Author(s)
Saikumar Jayalatha, Akshaya Keerthi
Ketelaar, Marlies E
Hesse, Laura
Badi, Yusef E
Zounemat-Kermani, Nazanin
Type
Journal Article
Abstract
IL-33 response in Th2 cells is specific to asthma and represents a high risk haplotype, highlighting its role in airway wall cells. Yet, its detection is challenging in bulk asthma transcriptomes due to the scarcity of effector Th2 cells. https://bit.ly/3WhuMbo
Date Issued
2024-06-20
Date Acceptance
2024-04-22
Citation
European Respiratory Journal, 2024, 63 (6)
ISSN
0903-1936
Publisher
European Respiratory Society
Journal / Book Title
European Respiratory Journal
Volume
63
Issue
6
Copyright Statement
©The authors 2024. This version is distributed under the terms of the Creative Commons Attribution Licence 4.0 (https://creativecommons.org/licenses/by/4.0/)
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/38843913
PII: 13993003.00005-2024
Subjects
Asthma
Gene Expression Regulation
Haplotypes
Humans
Interleukin-1 Receptor-Like 1 Protein
Interleukin-33
Interleukins
Polymorphism, Single Nucleotide
Th2 Cells
Publication Status
Published
Coverage Spatial
England
Article Number
2400005
Date Publish Online
2024-06-20