Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages

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Author(s)

Cosio, BG

Tsaprouni, L

Ito, K

Jazrawi, E

Adcock, IM

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Type

Journal Article

Date Issued

2004-09-06

Date Acceptance

2004-07-13

Citation

Journal of Experimental Medicine, 2004, 200 (5), pp.689-695

URI

http://hdl.handle.net/10044/1/31754

DOI

https://www.dx.doi.org/10.1084/jem.20040416

ISSN

1540-9538

Publisher

Rockefeller University Press

Start Page

689

End Page

695

Journal / Book Title

Journal of Experimental Medicine

Volume

200

Issue

5

Copyright Statement

© The Rockefeller University Press 2004

Sponsor

GlaxoSmithKline Services Unlimited

Mitsubishi Pharma Corporation

Boehringer Ingelheim International Gmbh

Grant Number

PN1213GSK

PN1236/MPC

N/A

Subjects

Science & Technology

Life Sciences & Biomedicine

Immunology

Medicine, Research & Experimental

Research & Experimental Medicine

IMMUNOLOGY

MEDICINE, RESEARCH & EXPERIMENTAL

histone deacetylase

theophylline

steroid resistance

COPD

interleukin-8

OBSTRUCTIVE PULMONARY-DISEASE

KAPPA-B

ALVEOLAR MACROPHAGES

OXIDATIVE STRESS

GENE-EXPRESSION

ASSOCIATION

SMOKERS

ASTHMA

ALPHA

Aged

Blotting, Western

Bronchodilator Agents

Enzyme-Linked Immunosorbent Assay

Female

Glutathione

Histone Deacetylases

Humans

Hydroxamic Acids

Immunohistochemistry

Inflammation

Interleukin-8

Lipopolysaccharides

Macrophages

Male

Middle Aged

Oxidative Stress

Pulmonary Disease, Chronic Obstructive

Smoking

Steroids

Theophylline

Tumor Necrosis Factor-alpha

U937 Cells

11 Medical And Health Sciences

Publication Status

Published