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  4. Acoustic streaming in a soft tissue microenvironment
 
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Acoustic streaming in a soft tissue microenvironment
File(s)
AG_UMB_pre_proof.pdf (1.34 MB)
Accepted version
Author(s)
El Ghamrawy, Ahmed
de Comtes, Florentina
Koruk, Hasan
Mohammed, Ali
Jones, Julian R
more
Type
Journal Article
Abstract
We demonstrated that sound can push fluid through a tissue-mimicking material. Although acoustic streaming in tissue has been proposed as a mechanism for biomedical ultrasound applications, such as neuromodulation and enhanced drug penetration, streaming in tissue or acoustic phantoms has not been directly observed. We developed a material that mimics the porous structure of tissue and used a dye and a video camera to track fluid movement. When applied above an acoustic intensity threshold, a continuous focused ultrasound beam (spatial peak time average intensity: 238 W/cm2, centre frequency: 5 MHz) was found to push the dye axially, that is, in the direction of wave propagation and in the radial direction. Dye clearance increased with ultrasound intensity and was modelled using an adapted version of Eckart's acoustic streaming velocity equation. No microstructural changes were observed in the sonicated region when assessed using scanning electron microscopy. Our study indicates that acoustic streaming can occur in soft porous materials and provides a mechanistic basis for future use of streaming for therapeutic or diagnostic purposes.
Date Issued
2019-01-01
Date Acceptance
2018-08-29
Citation
Ultrasound in Medicine and Biology, 2019, 45 (1), pp.208-217
URI
http://hdl.handle.net/10044/1/69520
DOI
https://www.dx.doi.org/10.1016/j.ultrasmedbio.2018.08.026
ISSN
0301-5629
Publisher
Elsevier
Start Page
208
End Page
217
Journal / Book Title
Ultrasound in Medicine and Biology
Volume
45
Issue
1
Copyright Statement
© 2019 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000451607300022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Technology
Life Sciences & Biomedicine
Acoustics
Radiology, Nuclear Medicine & Medical Imaging
Acousticstreaming
Porousmaterials
Drugdelivery
Focusedultrasound
THERAPEUTIC ULTRASOUND
DIAGNOSTIC ULTRASOUND
GEL
Publication Status
Published
Date Publish Online
2018-10-15
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