The engineering potential of Rhodosporidium toruloides as a workhorse for biotechnological applications
File(s)
Accepted version
Author(s)
Park, YK
Nicaud, JM
Ledesma Amaro, R
Type
Journal Article
Abstract
Moving our society towards a bioeconomy requires efficient and sustainable microbial production of chemicals and fuels. Rhodotorula (Rhodosporidium) toruloides is a yeast that naturally synthesizes substantial amounts of specialty chemicals and has been recently engineered to (i) enhance its natural production of lipids and carotenoids, and (ii) produce novel industrially relevant compounds. The use of R. toruloides by companies and research groups has exponentially increased in recent years as a result of recent improvements in genetic engineering techniques and the availability of multiomics information on its genome and metabolism. This review focuses on recent engineering approaches in R. toruloides for bioproduction and explores its potential as a biotechnological chassis.
Date Issued
2017-11-10
Date Acceptance
2017-11-10
Citation
Trends in Biotechnology, 2017, 36 (3), pp.304-317
ISSN
0167-7799
Publisher
Elsevier
Start Page
304
End Page
317
Journal / Book Title
Trends in Biotechnology
Volume
36
Issue
3
Copyright Statement
© 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Subjects
Science & Technology
Life Sciences & Biomedicine
Biotechnology & Applied Microbiology
PHENYLALANINE AMMONIA-LYASE
MICROBIAL LIPID PRODUCTION
AMINO-ACID OXIDASE
OLEAGINOUS YEAST
CRUDE GLYCEROL
BIODIESEL PRODUCTION
YARROWIA-LIPOLYTICA
CARBON SOURCE
WASTE-WATER
NCYC 921
Rhodosporidium toruloides
carotenoids
fatty acid-derived compounds
industrial biotechnology
lipids
metabolic engineering
synthetic biology
06 Biological Sciences
09 Engineering
10 Technology
Biotechnology
Publication Status
Published