Site-selective Suzuki-Miyaura coupling of heteroaryl halides - understanding the trends for pharmaceutically important classes
File(s)c6sc02118b.pdf (2.41 MB)
Published version
Author(s)
Almond-Thynne, J
Blakemore, DC
Pryde, DC
Spivey, AC
Type
Journal Article
Abstract
Suzuki–Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends found.
Date Issued
2016-08-09
Date Acceptance
2016-08-04
Citation
Chemical Science, 2016, 8 (1), pp.40-62
ISSN
2041-6539
Publisher
Royal Society of Chemistry
Start Page
40
End Page
62
Journal / Book Title
Chemical Science
Volume
8
Issue
1
Copyright Statement
© 2016 The Authors. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence (https://creativecommons.org/licenses/by-nc/3.0/).
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000391454500003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
ONE-POT SYNTHESIS
LIGHT-EMITTING-DIODES
BOND-DISSOCIATION ENERGIES
ESTROGEN-RECEPTOR LIGANDS
DINUCLEAR PD(I) COMPLEXES
ARYL BORONIC ACIDS
EFFICIENT SYNTHESIS
OXIDATIVE ADDITION
ARYLBORONIC ACIDS
KINASE INHIBITORS
Publication Status
Published