The Digital Brain Bank, an open access platform for post-mortem imaging datasets
File(s)
Author(s)
Type
Journal Article
Abstract
Post-mortem magnetic resonance imaging (MRI) provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy and validate the origins of image contrast through microscopy comparisons. We introduce the Digital Brain Bank (open.win.ox.ac.uk/DigitalBrainBank), a data release platform providing open access to curated, multimodal post-mortem neuroimaging datasets. Datasets span three themes—Digital Neuroanatomist: datasets for detailed neuroanatomical investigations; Digital Brain Zoo: datasets for comparative neuroanatomy; and Digital Pathologist: datasets for neuropathology investigations. The first Digital Brain Bank data release includes 21 distinctive whole-brain diffusion MRI datasets for structural connectivity investigations, alongside microscopy and complementary MRI modalities. This includes one of the highest-resolution whole-brain human diffusion MRI datasets ever acquired, whole-brain diffusion MRI in fourteen nonhuman primate species, and one of the largest post-mortem whole-brain cohort imaging studies in neurodegeneration. The Digital Brain Bank is the culmination of our lab’s investment into post-mortem MRI methodology and MRI-microscopy analysis techniques. This manuscript provides a detailed overview of our work with post-mortem imaging to date, including the development of diffusion MRI methods to image large post-mortem samples, including whole, human brains. Taken together, the Digital Brain Bank provides cross-scale, cross-species datasets facilitating the incorporation of post-mortem data into neuroimaging studies.
Date Issued
2022-03-17
Date Acceptance
2022-03-17
Citation
eLife, 2022, 11
ISSN
2050-084X
Publisher
eLife Sciences Publications Ltd
Journal / Book Title
eLife
Volume
11
Copyright Statement
Copyright © Tendler et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/35297760
PII: 73153
Subjects
AMYOTROPHIC-LATERAL-SCLEROSIS
Biology
CEREBRAL MRI
comparative neuroanatomy
data resource
DEGENERATION
DIFFUSION MRI
FORMALIN FIXATION
Human
human neuroanatomy
Life Sciences & Biomedicine
Life Sciences & Biomedicine - Other Topics
Microscopy
MODEL
MRI
neuropathology
Other
post-mortem
REGISTRATION
RELAXATION-TIMES
Science & Technology
STEADY-STATE
TRACTOGRAPHY
Publication Status
Published
Coverage Spatial
England
Article Number
ARTN e73153
Date Publish Online
2022-03-17