Multiple recombinant events in human T-Cell leukemia virus type 1: complete sequences of recombinant African strains.
Author(s)
Type
Journal Article
Abstract
Africa is the largest known endemic area for HTLV-1, with a high diversity of molecular genotypes. We previously demonstrated that some HTLV-1 strains from North Africa (the a-NA clade) are the result of a recombinant event between Senegalese and West African strains. To better characterize these recombinants and their distribution, we sequenced the LTR region and/or a env gene fragment of a series of 52 HTLV-1 strains from 13 different countries in North and West Africa. Four samples from descendants of African slaves and native to French Guiana were also added. Furthermore, we characterized the complete sequence for 7 viral strains, from the different genotypes. Until now, no complete sequence was available for a-NA clade. Phylogenetic analysis demonstrates that most of the new African strains belong to the Cosmopolitan a-genotype. Ten new strains from the recombinant North African (a-NA) clade could be found in Morocco, Western Sahara, Mali, Guinea, Côte d'Ivoire, and Ghana. We also identified a new clade (named a-G-Rec) comprising 4 strains from Guinea and Ghana that arose from a distinct recombination event between strains from Senegal and West Africa. The analyses of complete sequences suggest that recombination does not only occur in the LTR but also in other regions (env/pol) of the genome. Our data strongly suggest that a-NA and a-G-Rec strains have a mosaic profile with genetic segments deriving from either a-WA or a-Sen strains. In conclusion, our work demonstrates that recombination in HTLV-1 may not be such a rare event as previously proposed.
Date Issued
2020-05-13
Date Acceptance
2020-04-01
Citation
Emerging Microbes and Infections, 2020, 9 (1), pp.913-923
ISSN
2222-1751
Publisher
Nature Publishing Group
Start Page
913
End Page
923
Journal / Book Title
Emerging Microbes and Infections
Volume
9
Issue
1
Copyright Statement
© 2020 The Author(s). Published by Informa
UK Limited, trading as Taylor & Francis
Group, on behalf of Shanghai Shangyixun
Cultural Communication Co., Ltd. This is an Accepted Manuscript of an article published by Taylor & Francis in
Emerging Microbes & Infections on 06 April 2020, available online: https://doi.org/10.1080/22221751.2020.1752117
UK Limited, trading as Taylor & Francis
Group, on behalf of Shanghai Shangyixun
Cultural Communication Co., Ltd. This is an Accepted Manuscript of an article published by Taylor & Francis in
Emerging Microbes & Infections on 06 April 2020, available online: https://doi.org/10.1080/22221751.2020.1752117
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/32249692
Subjects
Africa
HTLV-1
HTLV-1 complete genome
molecular epidemiology
recombination
reverse transcription
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2020-04-06