Diagnostic value of comprehensive echocardiographic assessment including speckle-tracking in patients with sarcoidosis versus healthy controls: a systematic review and meta-analysis
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Background: Cardiac involvement in sarcoidosis is often subclinical, with late manifestations associated with poorer prognosis. Speckle-tracking echocardiography (STE) is gaining attention due to its ability to detect subclinical alterations in myocardial contraction patterns and quantification of abnormal parameters. Methods: Databases, including PubMed, Cochrane Central, Embase, Scopus, and Web of Science, were searched to identify studies comparing echocardiographic parameters in sarcoidosis patients with healthy controls. Mean difference (MD) with 95% confidence intervals (CI) were pooled using the inverse-variance random-effects model in Review Manager Version 5.4.1. Statistical significance was considered at p-value <0.05. Results: Thirteen studies with 1416 participants (854—sarcoidosis; 562—healthy controls) were included. In a pooled analysis, patients with sarcoidosis demonstrated a significantly lower left ventricular global longitudinal strain (LV GLS) (Mean Difference [MD]: −3.60; 95% Confidence Interval [CI]: −4.76, −2.43; p < 0.0001) and left ventricular global circumferential strain (LV GCS) (MD: −2.52; 95% CI: −4.61, −0.43; p = 0.02), along with a significantly higher pulmonary artery systolic pressure (PASP) (MD: 4.19; 95% CI: 0.08, 8.29; p = 0.05), left ventricular end-systolic diameter (LVESD) (MD: 0.90; 95% CI: 0.10, 1.71; p = 0.03), A-wave velocity (MD: 3.36; 95% CI: 0.33, 6.39; p = 0.03), and E/E’ ratio (MD: 1.33; 95% CI: 0.42, 2.23; p = 0.004) compared to healthy controls. No significant differences were noted in left ventricular ejection fraction (LVEF), left ventricular global radial strain (LV GRS), interventricular septal thickness (IVST), tricuspid annular plane systolic excursion (TAPSE), left ventricular end-diastolic diameter (LVEDD), E-wave velocity, and E/A ratio. Conclusions: STE serves as a promising imaging modality in detecting subclinical cardiac involvement in sarcoidosis patients with no overt cardiac manifestations. A widespread cardiovascular evaluation of sarcoidosis patients with STE is recommended to detect these altered myocardial contractile patterns. The early detection of cardiac sarcoidosis is essential to prevent adverse clinical outcomes and improve mortality.
Date Issued
2025-03-02
Date Acceptance
2025-03-11
Citation
Diagnostics, 2025, 15 (6)
ISSN
2075-4418
Publisher
MDPI AG
Journal / Book Title
Diagnostics
Volume
15
Issue
6
Copyright Statement
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).
License URL
Identifier
10.3390/diagnostics15060708
Subjects
Jain, H.
Shahzad, M.
Ahsan, M.
Patel, R.
Singh, J.
Odat, R.M.
Goyal, A.
Kelkar, R.
Barve, N.
Farrukh, H.
et al. Diagnostic Value of Comprehensive Echocardiographic Assessment Including Speckle-Tracking in Patients with Sarcoidosis Versus Healthy Controls: A Systematic −4.61, −0.43
p = 0.02), along with a significantly higher pulmonary artery systolic pressure (PASP) (MD: 4.19
95% CI: 0.08, 8.29
p = 0.05), left ventricular end-systolic diameter (LVESD) (MD: 0.90
95% CI: 0.10, 1.71
p = 0.03), A-wave velocity (MD: 3.36
95% CI: 0.33, 6.39
p = 0.03), and E/E' ratio (MD: 1.33
95% CI: 0.42, 2.23
p = 0.004) compared to healthy controls. No significant differences were noted in left ventricular ejection fraction (LVEF), left ventricular global radial strain (LV GRS), interventricular septal thickness (IVST), tricuspid annular sarcoidosis
echocardiography
doppler echocardiography
speckle tracking echocardiography
cardiac sarcoidosis
meta-analysis
Publication Status
Published
Article Number
708
Date Publish Online
2025-03-12