Model of reversible vesicular transport with exclusion
File(s)exclusionR1.pdf (526.75 KB)
Accepted version
Author(s)
Bressloff, Paul C
Karamched, Bhargav R
Type
Journal Article
Abstract
A major question in neurobiology concerns the mechanics behind the motor-driven transport and delivery of vesicles to synaptic targets along the axon of a neuron. Experimental evidence suggests that the distribution of vesicles along the axon is relatively uniform and that vesicular delivery to synapses is reversible. A recent modeling study has made explicit the crucial role that reversibility in vesicular delivery to synapses plays in achieving uniformity in vesicle distribution, so called synaptic democracy (Bressloff et al 2015 Phys. Rev. Lett. 114 168101). In this paper we generalize the previous model by accounting for exclusion effects (hard-core repulsion) that may occur between molecular motor-cargo complexes (particles) moving along the same microtubule track. The resulting model takes the form of an exclusion process with four internal states, which distinguish between motile and stationary particles, and whether or not a particle is carrying vesicles. By applying a mean field approximation and an adiabatic approximation we reduce the system of ODEs describing the evolution of occupation numbers of the sites on a 1D lattice to a system of hydrodynamic equations in the continuum limit. We find that reversibility in vesicular delivery allows for synaptic democracy even in the presence of exclusion effects, although exclusion does exacerbate nonuniform distributions of vesicles in an axon when compared with a model without exclusion. We also uncover the relationship between our model and other models of exclusion processes with internal states.
Date Issued
2016-08-26
Date Acceptance
2016-06-15
Citation
Journal of Physics A: Mathematical and Theoretical, 2016, 49 (34)
ISSN
1751-8113
Publisher
IOP Publishing
Journal / Book Title
Journal of Physics A: Mathematical and Theoretical
Volume
49
Issue
34
Copyright Statement
Copyright © 2016 IOP Publishing Ltd. This is an author-created, un-copyedited version of an article published in Journal of Physics A: Mathematical and Theoretical. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at 10.1088/1751-8113/49/34/345602
Identifier
http://dx.doi.org/10.1088/1751-8113/49/34/345602
Publication Status
Published
Article Number
345602
Date Publish Online
2016-07-22